The program of research across Optymise proposes that adolescent-onset and early intervention perspectives are critical to uncovering the multiple developmental paths that underpin adult mood disorders. Thus, utilising treatments based on putative pathophysiological paths that link adolescent-onset depression to adult type mood disorders will result in better clinical and functional outcomes.
The program has four research streams
i) Improving the delivery of current interventions
ii) Testing new behavioural or medical therapies
iii) Developing better clinical or objective measures for selecting treatments
iv) Evaluating strategies that engage young people more effectively in their own care
The key research studies that will be conducted in order to contribute new data to these research streams include:
i) New clinical efficacy or stepped care trials of existing interventions
ii) Phase II clinical trials of new therapies
iii) Collation of data from longitudinal, family and interventional studies, with an emphasis on large-scale evaluation of objective markers of disease progression
iv) Testing the feasibility of new methods of engagement of young people in their care
Improving the delivery of current interventions
This stream involves testing current interventions delivered to at risk groups, focusing on the ways in which key therapies may be delivered optimally in large clinical efficacy studies or stepped care approaches.
Testing new behavioural or medical therapies
This stream aims to encourage the continued development of new novel treatment trials.
Developing better clinical or objective measures for selecting treatments
This stream aims to collate clinical, longitudinal, neurobiological and functional outcome data from both clinical and population-based studies.
Evaluating strategies that engage young people more effectively in their own care
Key studies in this area of work are at the interface of new technologies for behavioural and biometric assessment. Additionally studies will assess of the degree of engagement of young people in their own long term health care and use new technologies to deliver health care services at scale.