This research is being conducted at the BMRI, University of Sydney and the Young Adult Mental Health Service, St Vincent’s Private Hospital. It will investigate the relationship between sleep-wake cycle, cognitive functioning and in vivo neurochemical concentrations and, responsiveness to repetitive transcranial magnetic stimulation (rTMS) treatment for depression. rTMS is a non-invasive procedure that has recently been shown to be efficacious for the treatment of depression with relatively fewer and less likely associated risks compared with electroconvulsive therapy.
Patients may be eligible for inclusion in this study if they are 18-30 years old, are experiencing current depression and who have not responded to previous antidepressant medication. Exclusion criteria include contraindication to MRI scanning, a diagnosis of epilepsy, mania, psychosis, high suicidal risk, severe restrictive eating disorders, major developmental disorders, current alcohol and other substance use disorders, major medical illness, intellectual disability or inability to provide informed consent, poor English speaking and, history of sustained head injury.
Participation will require a prescription for rTMS treatment to be administered at St Vincent’s Private Hospital for 20 minutes every weekday over 4 weeks. Participants will then undergo pre- and post-treatment psychiatric, neuropsychological and sleep-wake assessments, MRI scanning and self-report questionnaires. All pre- and post-treatment assessments will take place at the BMRI. A psychiatric assessment will also be carried out half way through the rTMS treatment course (i.e. after 2 weeks). There will be no cost associated with in this research for participants.
Please direct any enquiries to Dr Manreena Kaur (email: firstname.lastname@example.org; phone: 02 9351 0932).